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The IGF-1 MSIA-SRM provides a linear dynamic range spanning 11,500 ng/mL ( Figure 3 ), enabling a single assay to quantify IGF-1 over its biologically relevant concentrations and the ability to quantify as little as 5 femtomoles of IGF-1 from 40 mL human plasma

This work was supported in part by funding to M.J.B

A dose that produces a given plasma concentration in a 40-year-old will not produce the same concentration in a 14-year-old of the same body weight

Molecular Weight: ~390 Da

The popularity of coffee enemas declined during the 20th century and their citation as a folk medical practice was removed from the best-selling textbook Merck Manual in 1972